Mana Shankara Vara Prasad Garu explores the story of Shankara Varaprasad, a national security officer with the NIA. He is married to Sasirekha, the daughter of a wealthy man, who marries Shankara despite her father’s disapproval of him for being from a middle-class background.
Due to his disapproval, Sasirekha’s father becomes an obstacle in the couple’s relationship. Following a series of misunderstandings, Shankara and Sasirekha separate, even though they still have feelings for each other.
As Shankara is assigned a new mission, he must also navigate his fractured relationship and attempt to mend it, exploring whether he manages to reunite with his wife.
With Chiranjeevi in the lead role, the film features Nayanthara as the female co-lead. Apart from them, the movie stars Catherine Tresa, Zarina Wahab, Harsha Vardhan, Abhinav Gomatam, Sachin Khedekar, Sharat Saxena, Sudev Nair, Srinivasa Reddy, Harsha Chemudu, and several others in key roles.
Additionally, Venkatesh Daggubati appears in an extended cameo as a pivotal character in the film. Written and directed by Anil Ravipudi, the movie has music composed by Bheems Ceciroleo.